MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01CBC069.83332FA0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01CBC069.83332FA0 Content-Location: file:///C:/5F66424E/Cyt_P450-2C19-Gentyp-Simon.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Клиническl= 0;е события как функция применения использоваl= 5;ия ингибитороk= 4; протонного насоса, применения клопидогреl= 3;а, и генотипа цитохрома P450 2C19 в крупной общенационk= 2;льной когорте больных острым инфарктом миокарда

Клиническ = 80;е события как функция исп = 86;льзования ингибитороk= 4; протонного = 85;асоса, применения клопидогреl= 3;а, и генотипа цитохрома P450 2C19 в крупной общенационk= 2;льной когорте больных острым инфарктом миокарда.=

Результат = 99; из Французскоk= 5;о регистра oстрого инфаркта миокарда с подъемами и без подъемо = 74; ST.

Clinical Events as a Function of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genotype in a Large Nationwide Cohort of Acute Myocardial Infarction. Results From the French R= egistry of Acute ST-Elevation and Non–ST-Elevation Myocardial Infarction (FAST-MI) Registry.

 

 

См. также [ 1 ], [ 2 ]

 

Продолжаю&#= 1090; накапливатn= 0;ся сведения о клиническиm= 3; эффектах сочетания клопидогреl= 3;а и ингибитороk= 4; протонного = 85;асоса. Только что опубликоваl= 5;ы результаты тщательногl= 6; анализа данных Французскоk= 5;о регистра oстрого инфаркта миокарда. Авторы считают, что они «не поддерживаn= 2;т воздержаниn= 3; от применен = 80;я ИПН у больны= 093; с высоким риском кров = 86;течений, получающих клопидогреl= 3;». Приводим перевод резюме публикации [1].=

 

= «Предп&#= 1086;сылки.
Клопидогреl= 3; требует метаболичеl= 9;кого активироваl= 5;ия цитохромом P450 2C19 (CYP2C19). Ингибиторы = 87;ротонного насоса (ИПН), которые ингибируют CYP2= C19, обычно применяютсn= 3; вместе с клопидогреl= 3;ом для уменьшения риска желуд = 86;чно-кишечны&= #1093; кровотеченl= 0;й. В настоящем анализе сравнены исходы лечения пац = 80;ентов во Французскоl= 4; регистре острого инф = 72;ркта миокарда с подъемами и без подъемо = 74; ST (FAST-MI), принимавшиm= 3; и не принимавшиm= 3; клопидогреl= 3; и/или ИПН.

= Методы и результаты.
В регистр FAST-MI включены 3670 пациентов (в том числе 2744 ранее не при= 085;имавших клопидогреl= 3; и ИПН - clopidogrel- and PPI-naïve patients) с определён = 85;ым инфарктом миокарда. Пациенты были категоризиl= 8;ованы в соответст = 74;ии с использоваl= 5;ием клопидогреl= 3;а и/или ИПН в пределах 48 час после госпитализk= 2;ции поступлениn= 3; в больницу.

= Пр= 080;менение ИПН не было сопряжено с увеличенныl= 4; риском какого либо из основных внутригоспl= 0;тальных событий (выживание в период госпитализk= 2;ции, реинфаркт, инсульт, кровотеченl= 0;е, и трансфузия). Лечени&#= 1077; ИПН не было также независимыl= 4; предиктороl= 4; выживания в течение 1 года (отноше= 085;ие рисков 0.97; 95% дов<= span style=3D'color:#00000A'>ерител&#= 1100;ный интервал [ДИ], = 0.87 до 1.08; р=3D0.57) или возникновеl= 5;ия течение 1 года ин&#= 1092;аркта миокарда, инсульт&#= 1072;, или смерти (= отношен&#= 1080;е  рисков, 0.98; 95% ДИ, 0.90 до 1.08; р=3D0.72).

= Ра= 079;личий [между принимавшиl= 4;и и не принима= 074;шими ИПН] не было обнаружено = 80; если во вним= 072;ние принималисn= 0; тип ИПН или генотип CYP2C19. В когортах, сопоставимm= 9;х по пр&#= 1077;допределен= ности (propensity) лечения, отношения шансов серьезных внутригоспl= 0;тальных событий при применении ИПН по отнош= 077;нию к их непримененl= 0;ю были равны 0.29 (95% ДИ, 0.06 до 1.44) и 1.70 (95% ДИ, 0.10 до 30.3) соответствk= 7;нно среди пациентов с = 086;дной и двумя вариантнымl= 0; аллелями. У переживших госпитализk= 2;цию отношения рисков собы = 90;ий на протяжении 1 года были соответствk= 7;нно 0.68 (95% ДИ, 0.26 до 1.79) и 0.55 (95% ДИ, 0.06 до 5.30).

= Заключени = 77;. Использоваl= 5;ие ИПН не было сопряжено с повышенным риском сердечносоl= 9;удистых событий или смертности = 91; пациентов, получавших клопидогреl= 3; в связ&#= 1080; с недавним инфарктом миокарда, независимо от генотипа CYP2C19, хотя формально вред не мог быть исключен у пациентов с 2 аллелями утраты функции».

 

Ри= 089;.1.

 

Ри= 089;. 2

 

= 048;з заключения публикации.

«Испол&= #1100;зование ИПН не было сопряжено с повышенным риском сердечносоl= 9;удистых событий или смертности = 91; больных, леченных кл = 86;пидогрелом в связи с развившимсn= 3; инфарктом миокарда. Поэтому, на настоящий момент наши результаты не поддерживаn= 2;т воздержаниn= 3; от применен = 80;я ИПН у больны= 093; с высоким риском кров = 86;течений, получающих клопидогреl= 3;, особенно у пациентов, н= 077; имеющих аллелей утраты функ = 94;ии CYP2C19. Однак = 86; для подтверждеl= 5;ия этих резуль = 90;атов требуются дальнейшие рандомизирl= 6;ванные исследованl= 0;я».

 

= 048;сточник

1. <= /span>Simon T., Steg P.G., Gilard M., Blanchard D., Bonello L., M. Hanssen, Lardoux H., Coste P., Lefèvre T., Drouet E., Mulak G., Bataille V., Ferrières J., Verstuyft C., Danchin N. Clinical Events as a Function= of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genoty= pe in a Large Nationwide Cohort of Acute Myocardial Infarction. Results From t= he French Registry of Acute ST-Elevation and Non–ST-Elevation Myocardial= Infarction (FAST-MI) Registry. <= span lang=3DEN-US style=3D'font-size:14.0pt;mso-ansi-language:EN-US;mso-bidi-fon= t-weight: bold;mso-bidi-font-style:italic'>Circulation 2011; 123: 474-482.

=  

См. также [ 1 ], [ 2 ]

=  

= Под&= #1075;отовлено Н.А.Гра= цианским
Размещено 30/01/2011<= /span>

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