MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01CBC085.64F0B0F0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01CBC085.64F0B0F0 Content-Location: file:///C:/EF543DE5/NSAID-CVsafety-rus-abst-Trelle.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Сердечносl= 6;судистая безопасносm= 0;ь

Сердечносо&= #1089;удистая безопасносm= 0;ь

нестероидн&= #1099;х противовосl= 7;алительных средств:

сетевой мета-анализ.

Cardiovascular safety of non-steroid= al anti-inflammatory drugs:
network meta-analysis

 

См. также [_1= _], [_2= _], [_3_]

 

В крупнейшем метаанализk= 7; суммированm= 9; данные о частоте сердечносоl= 9;удистых событий в испытаниях нестероиднm= 9;х противовосl= 7;алительных лекарств. Пр= 080;водим перевод резюме соответствm= 1;ющей публикации [1].=

 

«Цель.
Проана = 83;изировать имеющиеся данные о сер= 076;ечнососуди&= #1089;той безопасносm= 0;и нестероиднm= 9;х противовосl= 7;алительных лекарств (ср= 077;дств).

Структу = 88;а, план.
Сетево = 81; метаанализ.

Источ = 85;ики данных.
Библио = 75;рафические базы данных, труды конференциl= 1;, регистры ис = 89;ледований, интернет са = 81;т Администраm= 4;ии США по пищевым продуктам и лекарствам, списки литературы имеющих отн = 86;шение к проблеме статей и соо= 073;щения, цитирующие такие стать = 80; в Science Citation Index (последнее обновление - июль 2009 г.). Производитk= 7;ли целекоксибk= 2; и лумиракок = 89;иба предоставиl= 3;и дополнителn= 0;ные данные.

Отбор исследованl= 0;й.
Все крупномасшm= 0;абные рандомизирl= 6;ванные испытания, сравнивавшl= 0;е любое нестероиднl= 6;е противовосl= 7;алительное средство с другим нестероиднm= 9;м противовосl= 7;алительным средством или с п&= #1083;ацебо. Два ис&#= 1089;ледователя независимо оценивали, соответствm= 1;ет ли исследованl= 0;е критериям о = 90;бора.

Извлеч = 77;ние данных.
Первич = 85;ым ис&= #1093;одом был инфаркт миокарда. Вт&= #1086;ричные исходы включали инсульт, смерть от сердечносоl= 9;удистого заболеваниn= 3;, или смерть о= 090; любой причи = 85;ы. Данные экстрагироk= 4;али. два исследоватk= 7;ля независимо друг от друг= 072;.

Синте = 79; данных.
Включе = 85;о 31 испытание на 116429 пациентах с длительносm= 0;ью наблюдения более чем 115000 человеко-ле = 90;.
Пациенты были распределеl= 5;ы к напроксен = 91;, ибупрофену, диклофенакm= 1;, целекоксибm= 1;, эторикоксиk= 3;у, рофекоксибm= 1;, лумиракоксl= 0;бу, или плацебо. По сра&#= 1074;нению с плацебо с наиболее высоким риском инфаркта миокарда ассоции&#= 1088;овался рофекоксиб (отношен&#= 1080;е частот 2.12, 95% до&= #1074;ерительный [credibility] интервал 1.26 до 3.56), За ним следовал лумиракоксl= 0;б (2.00, 0.71 до 6.21).
С наиболее высоким риском инсульта было сопряжено применение ибупрофена (3.3= 6, 1.00 до 11.6), за ним следовал диклофенак (2.8= 6, 1.09 до 8.36).
Примен= 077;ние эторикоксиk= 3;а и дилофенак = 72; ассоциировk= 2;лось с наиболее высоким риском сердечносоl= 9;удистой смерти.

Заключе = 85;ие. Хотя нек&= #1086;торая неопределеl= 5;ность сохраняетсn= 3;, существует = 84;ало оснований для предположеl= 5;ия, что как&#= 1086;е-либо из включенных = 74; анализ средств без = 86;пасно в сердечносоl= 9;удистом отношении. Наименее вредным представляk= 7;тся напроксен. С= 077;рдечнососу&= #1076;истый риск должен приниматьсn= 3; во внимание (учитыватьс = 03;) при назначении = 83;юбого нестероиднl= 6;го противовосl= 7;алительног= 086; лекарства».

 

Рис.

 

 

Источник

Trelle S., Reichenbach= S., Wandel S., Hildebrand P., Tschannen B., Villiger P.M., Egger M., Jüni = P. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011; 342:c7086. <= span style=3D'font-size:14.0pt;mso-bidi-font-size:10.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:RU'>

 

См. также [_1= _], [_2= _], [_3_]

.

 

Подготовле&= #1085;о Н.А.Грацианс= 082;им
Размещено 30.01.2011<= o:p>

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