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Сердечносо&=
#1089;удистая
безопасносm=
0;ь
нестероидн&=
#1099;х
противовосl=
7;алительных
средств: =
p>
сетевой
мета-анализ.
Cardiovascular safety of non-steroid=
al
anti-inflammatory drugs:
network meta-analysis
См.
также [_1=
_],
[_2=
_],
[_3_]
В
крупнейшем
метаанализk=
7;
суммированm=
9;
данные о
частоте
сердечносоl=
9;удистых
событий в
испытаниях
нестероиднm=
9;х
противовосl=
7;алительных
лекарств. Пр=
080;водим
перевод
резюме
соответствm=
1;ющей
публикации [1].=
«Цель.
Проана
=
83;изировать
имеющиеся
данные о сер=
076;ечнососуди&=
#1089;той
безопасносm=
0;и
нестероиднm=
9;х
противовосl=
7;алительных
лекарств (ср=
077;дств).
Структу
=
88;а,
план.
Сетево
=
81;
метаанализ.
Источ
=
85;ики
данных.
Библио
=
75;рафические
базы данных,
труды
конференциl=
1;,
регистры ис
=
89;ледований,
интернет са
=
81;т
Администраm=
4;ии
США по
пищевым
продуктам и
лекарствам,
списки
литературы
имеющих отн
=
86;шение
к проблеме
статей и соо=
073;щения,
цитирующие
такие стать
=
80; в Science Citation Index
(последнее
обновление -
июль 2009 г.).
Производитk=
7;ли
целекоксибk=
2;
и лумиракок
=
89;иба
предоставиl=
3;и
дополнителn=
0;ные
данные.
Отбор
исследованl=
0;й.
Все
крупномасшm=
0;абные
рандомизирl=
6;ванные
испытания,
сравнивавшl=
0;е
любое
нестероиднl=
6;е
противовосl=
7;алительное
средство с
другим
нестероиднm=
9;м
противовосl=
7;алительным
средством
или с п&=
#1083;ацебо.
Два ис=
1089;ледователя
независимо
оценивали,
соответствm=
1;ет
ли
исследованl=
0;е
критериям о
=
90;бора.
Извлеч
=
77;ние
данных.
Первич
=
85;ым ис&=
#1093;одом
был инфаркт
миокарда. Вт&=
#1086;ричные исходы
включали
инсульт,
смерть от
сердечносоl=
9;удистого
заболеваниn=
3;,
или смерть о=
090;
любой причи
=
85;ы.
Данные
экстрагироk=
4;али.
два
исследоватk=
7;ля
независимо
друг от друг=
072;.
Синте
=
79;
данных.
Включе
=
85;о
31 испытание
на 116429
пациентах с
длительносm=
0;ью
наблюдения
более чем 115000
человеко-ле
=
90;.
Пациенты
были
распределеl=
5;ы
к напроксен
=
91;,
ибупрофену,
диклофенакm=
1;,
целекоксибm=
1;,
эторикоксиk=
3;у,
рофекоксибm=
1;,
лумиракоксl=
0;бу,
или плацебо.
По сра=
1074;нению
с плацебо с
наиболее
высоким
риском
инфаркта
миокарда ассоции=
1088;овался
рофекоксиб (отношен=
1080;е
частот 2.12, 95% до&=
#1074;ерительный
[credibility] интервал 1.26 до
3.56), За ним
следовал
лумиракоксl=
0;б
(2.00, 0.71 до 6.21).
С наиболее
высоким
риском
инсульта
было
сопряжено
применение
ибупрофена (3.3=
6,
1.00 до 11.6), за ним
следовал
диклофенак (2.8=
6,
1.09 до 8.36).
Примен=
077;ние
эторикоксиk=
3;а
и дилофенак
=
72;
ассоциировk=
2;лось
с наиболее
высоким
риском
сердечносоl=
9;удистой
смерти.
Заключе
=
85;ие. Хотя нек&=
#1086;торая
неопределеl=
5;ность
сохраняетсn=
3;,
существует
=
84;ало
оснований
для
предположеl=
5;ия,
что как=
1086;е-либо
из
включенных
=
74;
анализ
средств без
=
86;пасно
в
сердечносоl=
9;удистом
отношении.
Наименее
вредным
представляk=
7;тся
напроксен. С=
077;рдечнососу&=
#1076;истый
риск должен
приниматьсn=
3;
во внимание
(учитыватьс=
03;)
при
назначении
=
83;юбого
нестероиднl=
6;го
противовосl=
7;алительног=
086;
лекарства».
Рис. =
span>

Источник
Trelle S., Reichenbach=
S.,
Wandel S., Hildebrand P., Tschannen B., Villiger P.M., Egger M., Jüni =
P.
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network
meta-analysis. BMJ 2011; 342:c7086. <=
span
style=3D'font-size:14.0pt;mso-bidi-font-size:10.0pt;mso-fareast-font-family=
:Tahoma;
mso-ansi-language:RU'>
См.
также [_1=
_],
[_2=
_],
[_3_]
.
Подготовле&=
#1085;о
Н.А.Грацианс=
082;им
Размещено 30.01.2011<=
o:p>
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